ZeClinics SL

General information

ZeClinics strength lies on our extensive experience in zebrafish research and our permanent collaboration with academics, imaging processing experts and other biotech companies, which allow us to perform and improve high-throughput assays to test the safety of chemical compounds with pharmaceutical, cosmetic or nutritional potential.

We also offer a growing portfolio of efficacy assays to test the biomedical relevance of novel compounds in the fields of oncology and neural disorders. However, our main value is our capacity to listen to your requirements and develop custom assays to test compounds in many biomedical contexts such as metabolism, anti-microbiology or other diseases. We are also happy to collaborate with you, when you need a partner to take promising molecules to the next level or test your research hypothesis using zebrafish.

Long-term toxicity can be predicted from studies during early life-stages, making zebrafish larvae a suitable model for toxicology screening. ZeClinics initiates every molecule safety study by testing its Acute Toxicity. This assay allows to assess its possible lethality and teratogenicity and provides values of LC50, EC50 and NOEC. To warrant the safety of any given molecule, the NOEC is tested for putative toxic effects on specific tissues known to be affected by novel drugs: Liver (Hepatotoxicity), Heart (Cardiotoxicity) and CNS (Neurotoxicity).

Up to 87% of genes implicated in human diseases have functional homologues in zebrafish. Morpholinos and genome-editing technologies allow for the generation of mutants/genetic disease models for a deeper understanding on the disease biology and high-throughput drug discovery. ZeClinics provides its expertise in transgenic manipulation and zebrafish biology for generating mutant and knock-in lines, phenotyping and use for custom drug screenings.

- Morpholino knockdown of the gene of interest and co-injection with different human versions of the gene (wild types and polymorphics).
– Null mutant and Custom mutant generation.
– High-throughput phenotyping assay to validate your model.
– Customized drug screening pipelines for testing efficacy of novel molecules in the unique zebrafish disease model.